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It can be used to capture both upside and downside moves on all time frames. When a buy pattern occurs it signals a strong likelihood that there is another move higher coming, whereas a ABC sell pattern indicates another move lower is coming. No strategy works all the time, but it can help you stay on the right side of the market, and also spot when it is turning against you.

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The MLM-LOCO analysis is computationally less efficient but more powerful as compared with the MLM analysis including the candidate ( --mlma ). By default, in order to improve computational efficiency, the phenotype will be adjusted by the mean and covariates, and the adjusted phenotype will subsequently be used for testing SNP association.

However, if SNPs are correlated with the covariates, pre-adjusting the phenotype by the covariates will probably cause loss of power. If this option is specified, the covariates will be fitted together with the SNP for association test.