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For example, larger sample sizes are required when common SNPs explain less variance (i.SNP heritability is low), which can be due to, for example, common SNPs being not in sufficient linkage disequilibrium (LD) with the causal variants or total heritability being low. In the risk-profiling framework, prediction efficacy (e.the amount of variance that can be explained by the GRPS) depends on the sample size of the discovery sample whereas the ability to detect variance explained that is significantly larger than zero depends on the size of the target sample.