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(Strong recommendation, low quality of evidence). Evidence that resolution of diarrhea after treatment for CDI is associated with development of immune responses in the host includes a rise in anti-toxin antibodies after successful therapy (121,122,123), and lower levels of IgG anti-toxin A antibodies in patients with RCDI compared with those with CDI develop RCDI (82).

Thus, there has been interest in immune approaches to treat both severe (refractory) and recurrent RCDI. Many patients also received concomitant standard therapy, making interpretation of efficacy difficult.

Passive immunizations with IVIG have been reported to be successful in several small series, including both children and adults.